Snutch T P, Reiner P B
Biotechnology Laboratory, University of British Columbia, Vancouver, Canada.
Curr Opin Neurobiol. 1992 Jun;2(3):247-53. doi: 10.1016/0959-4388(92)90111-w.
The past year has seen some significant advances in our understanding of the structural and functional properties of neuronal voltage-gated Ca2+ channels. Molecular cloning and protein purification studies have identified structural components, and expression studies are beginning to define the biophysical and pharmacological properties of the cloned channels. A number of studies of native Ca2+ channels show that the concept of channel modulation includes gating by both voltage and ligands.
在过去的一年里，我们对神经元电压门控Ca2+通道的结构和功能特性的理解取得了一些重大进展。分子克隆和蛋白质纯化研究已经确定了其结构成分，并且表达研究也开始明确克隆通道的生物物理和药理学特性。多项针对天然Ca2+通道的研究表明，通道调节的概念包括电压门控和配体门控。
