台湾正常个体及头颈癌患者中A型和B型EB病毒的分布情况。

Distribution of type A and type B EBV in normal individuals and patients with head and neck carcinomas in Taiwan.

作者信息

Shu C H, Chang Y S, Liang C L, Liu S T, Lin C Z, Chang P

机构信息

Department of Otolaryngology, Veterans General Hospital-Taipei, Taiwan.

出版信息

J Virol Methods. 1992 Jul;38(1):123-30. doi: 10.1016/0166-0934(92)90175-d.

DOI:10.1016/0166-0934(92)90175-d

PMID:1322927

Abstract

The subtypes of Epstein-Barr virus (EBV) according to the EBNA 2 gene were investigated in Taiwan by the polymerase chain reaction (PCR) and by Southern blot hybridization. The materials included 53 nasopharyngeal carcinoma (NPC) biopsies, 49 other head and neck cancers and 32 throat washings of normal individuals. EBV DNA was found in all NPC biopsies, 27 of 49 other head and neck carcinomas and 81% of normal individuals. Type A EBV was the predominant type of EBV in both normal individuals and patients with head and neck carcinomas in Taiwan. Type B EBV or coexistence of the A and B types comprised a small number of samples in this study.

摘要

在台湾，通过聚合酶链反应（PCR）和Southern印迹杂交技术，对根据EBNA 2基因分类的爱泼斯坦-巴尔病毒（EBV）亚型进行了研究。材料包括53份鼻咽癌（NPC）活检样本、49份其他头颈癌样本以及32份正常个体的咽漱液样本。在所有NPC活检样本、49份其他头颈癌样本中的27份以及81%的正常个体中均发现了EBV DNA。在台湾，A型EBV是正常个体和头颈癌患者中EBV的主要类型。在本研究中，B型EBV或A、B型共存的样本数量较少。