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鉴定一种与髓系分化初级反应基因以及单纯疱疹病毒神经毒力相关基因具有相似性的非洲猪瘟病毒基因。

Identification of an African swine fever virus gene with similarity to a myeloid differentiation primary response gene and a neurovirulence-associated gene of herpes simplex virus.

作者信息

Sussman M D, Lu Z, Kutish G, Afonso C L, Roberts P, Rock D L

机构信息

Plum Island Animal Disease Center, Agricultural Research Service, USDA, Greenport, New York 11944.

出版信息

J Virol. 1992 Sep;66(9):5586-9. doi: 10.1128/JVI.66.9.5586-5589.1992.

DOI:10.1128/JVI.66.9.5586-5589.1992
PMID:1323711
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC289119/
Abstract

Here we describe an open reading frame (LMW23-NL) in the African swine fever virus genome that possesses striking similarity to a murine myeloid differentiation primary response gene (MyD116) and the neurovirulence-associated gene (ICP34.5) of herpes simplex virus. In all three proteins, a centrally located acidic region precedes a highly conserved, hydrophilic 56-amino-acid domain located at the carboxy terminus. LMW23-NL predicts a highly basic protein of 184 amino acids with an estimated molecular mass of 21.3 kDa. The similarity of LMW23-NL to genes involved in myeloid cell differentiation and viral host range suggests a role for it in African swine fever virus host range.

摘要

在此，我们描述了非洲猪瘟病毒基因组中的一个开放阅读框（LMW23-NL），它与小鼠髓样分化初级反应基因（MyD116）以及单纯疱疹病毒的神经毒力相关基因（ICP34.5）具有显著相似性。在这三种蛋白质中，位于中央的酸性区域之前是位于羧基末端的一个高度保守的亲水性56个氨基酸的结构域。LMW23-NL预测为一种由184个氨基酸组成的高度碱性蛋白质，估计分子量为21.3 kDa。LMW23-NL与参与髓样细胞分化和病毒宿主范围的基因的相似性表明它在非洲猪瘟病毒宿主范围中发挥作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0bb/289119/0d4e44d5b9ad/jvirol00167-0421-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0bb/289119/0d4e44d5b9ad/jvirol00167-0421-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0bb/289119/0d4e44d5b9ad/jvirol00167-0421-a.jpg

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The herpes simplex virus (HSV) protein ICP34.5 is a virion component that forms a DNA-binding complex with proliferating cell nuclear antigen and HSV replication proteins.单纯疱疹病毒（HSV）蛋白ICP34.5是一种病毒体成分，它与增殖细胞核抗原和HSV复制蛋白形成DNA结合复合物。
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