羰基氰化物间氯苯腙对金黄色葡萄球菌积累KB - 5246无影响。
Lack of effect of carbonyl cyanide m-chlorophenylhydrazone on KB-5246 accumulation by Staphylococcus aureus.
作者信息
Kotera Y, Inoue Y, Ohashi M, Ito K, Inoue M
机构信息
New Drug Research Laboratories, Kanebo, Ltd., Osaka, Japan.
出版信息
Antimicrob Agents Chemother. 1992 Apr;36(4):883-5. doi: 10.1128/AAC.36.4.883.
Abstract
The accumulation of KB-5246 in a quinolone-susceptible strain of Staphylococcus aureus was about 70 times that of norfloxacin. Carbonyl cyanide m-chlorophenylhydrazone increased the accumulation of norfloxacin about eightfold, but it did not influence that of KB-5246. The low efflux of KB-5246 from S. aureus may contribute to its potent antibacterial activity.
摘要
KB - 5246在对喹诺酮敏感的金黄色葡萄球菌菌株中的蓄积量约为诺氟沙星的70倍。羰基氰化物间氯苯腙使诺氟沙星的蓄积量增加约8倍，但对KB - 5246的蓄积量没有影响。KB - 5246从金黄色葡萄球菌中的低外排可能有助于其强大的抗菌活性。
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