Walsh G M, Tsuchiya M, Frohlich E D
J Appl Physiol. 1976 May;40(5):849-53. doi: 10.1152/jappl.1976.40.5.849.
The direct Fick procedure for cardiac output determination in rat was validated by simultaneous comparison with electromagnetic flowmeter techniques. Significant coefficients of correlation were obtained between absolute cardiac output values (r = 0.789, P less than 0.001), increases (r = 0.768, P less than 0.001) and decreases (r = 0.672, P less than 0.01) in cardiac output detected by the two methods. As demonstrated in other species, cardiac output values of the Fick procedure in the rat were between 40 and 58% greater than respective electromagnetic flow probe values; however, percent changes in cardiac output obtained by the two methods were similar. The larger values of cardiac output obtained by the direct Fick method may be related, to a great extent, to the distribution of blood flow to the coronary and bronchial circulations. Fick cardiac output measurements were reproducible within rats, and the degree of variation in values among rats was similar to that obtained with the flowmeter procedure. The result indicate that the Fick meth od provides a valid estimation of cardiac output in the rat, with the ability to detect moderate changes (22-36%) in cardiac output.
通过与电磁流量计技术同时进行比较，验证了大鼠心输出量测定的直接菲克法。两种方法检测的绝对心输出量值之间（r = 0.789，P < 0.001）、心输出量增加（r = 0.768，P < 0.001）和减少（r = 0.672，P < 0.01）之间均获得了显著的相关系数。如在其他物种中所证明的那样，大鼠菲克法的心输出量值比相应的电磁流量探头值大40%至58%；然而，两种方法获得的心输出量百分比变化相似。直接菲克法获得的较大心输出量值在很大程度上可能与冠状动脉和支气管循环的血流分布有关。菲克心输出量测量在大鼠体内具有可重复性，并且大鼠之间值的变化程度与流量计测量程序获得的相似。结果表明，菲克法能够有效估计大鼠的心输出量，并能够检测心输出量的中度变化（22% - 36%）。
