Noe F E, Whitty A J, Davies K R
Acta Anaesthesiol Scand. 1981 Feb;25(1):12-6. doi: 10.1111/j.1399-6576.1981.tb01597.x.
Cardiac output was measured by both indocyanine green dye dilution and the direct Fick method using computer-calculated values for oxygen consumption and carbon dioxide excretion in eight mechanically ventilated dogs anesthetized with pentobarbital, with either tubocurarine or succinylcholine intravenous drip for neuromuscular relaxation. Sequential measurements were made during the anesthesia and in response to pharmacologically induced increased cardiac output using doxapram hydrochloride (1.5 mg/kg) given intravenously. The purpose of this project was to investigate the accuracy and reliability of the direct Fick measurements during anesthesia using computer-calculated measurements of pulmonary gas exchange and, since, these measurements have not been reported in detail previously, to establish tentative control values for future projects. The correlation of dye and direct Fick measurements of cardiac output during the first hour after induction of anesthesia was very good (r = 0.85 for all dye-carbon dioxide Fick values; r = 0.83 for all dye-oxygen Fick values.
采用吲哚菁绿染料稀释法和直接菲克法，利用计算机计算的耗氧量和二氧化碳排出量值，对8只戊巴比妥麻醉、静脉滴注筒箭毒碱或琥珀酰胆碱以实现神经肌肉松弛的机械通气犬进行心输出量测量。在麻醉期间以及静脉注射盐酸多沙普仑（1.5mg/kg）诱导心输出量增加时进行连续测量。本项目的目的是研究在麻醉期间使用计算机计算的肺气体交换测量值时直接菲克测量的准确性和可靠性，并且由于此前尚未详细报道过这些测量值，因此要为未来项目建立暂定对照值。麻醉诱导后第一小时内心输出量的染料测量值与直接菲克测量值的相关性非常好（所有染料 - 二氧化碳菲克值的r = 0.85；所有染料 - 氧气菲克值的r = 0.83）。
