Tallaksen-Greene S J, Young A B, Penney J B, Beitz A J
Department of Veterinary Biology, University of Minnesota, St. Paul.
Neurosci Lett. 1992 Jul 6;141(1):79-83. doi: 10.1016/0304-3940(92)90339-9.
Quantitative autoradiography was used to examine the density and distribution of excitatory amino acid (EAA) binding site subtypes in the principal sensory and spinal trigeminal nuclei of the rat trigeminal complex. The highest densities of N-methyl-D-aspartate (NMDA), alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA), kainate and metabotropic receptors were found in the superficial laminae (I and II) of subnucleus caudalis, a region known to be densely innervated by primary afferent nociceptive terminals. Lower densities of EAA binding sites were observed in spinal subnuclei interpolaris and oralis and within the principal sensory nucleus. These results are consistent with the hypothesis that EAAs are involved in primary afferent nociceptive neurotransmission.
采用定量放射自显影术检测大鼠三叉神经复合体主要感觉核和三叉神经脊束核中兴奋性氨基酸（EAA）结合位点亚型的密度和分布。在尾侧亚核的浅层层（I层和II层）中发现了N-甲基-D-天冬氨酸（NMDA）、α-氨基-3-羟基-5-甲基异恶唑-4-丙酸（AMPA）、海人藻酸和代谢型受体的最高密度，该区域已知由初级传入伤害性感受器末梢密集支配。在三叉神经中极核和口核以及主要感觉核内观察到较低密度的EAA结合位点。这些结果与EAA参与初级传入伤害性神经传递的假说一致。
