Johnson C C, Wendeler M, Levison M E
Department of Medicine, Medical College of Pennsylvania, Philadelphia 19129.
Antimicrob Agents Chemother. 1990 Aug;34(8):1597-9. doi: 10.1128/AAC.34.8.1597.
The in vitro activity of trospectomycin against 97 clinical isolates of oral pigmented Bacteroides species was compared with the activities of five other antimicrobial agents. At 4 micrograms/ml, more than 90% of isolates were inhibited by trospectomycin. Overall, strains that produced beta-lactamase (n = 41) were more resistant to trospectomycin, penicillin G, cefoxitin, piperacillin, and tetracycline but not to clindamycin. In this study, trospectomycin had excellent in vitro activity against oral pigmented Bacteroides species.