Johnson C C, Wendeler M, Levison M E
Department of Medicine, Medical College of Pennsylvania, Philadelphia 19129.
Antimicrob Agents Chemother. 1990 Aug;34(8):1597-9. doi: 10.1128/AAC.34.8.1597.
The in vitro activity of trospectomycin against 97 clinical isolates of oral pigmented Bacteroides species was compared with the activities of five other antimicrobial agents. At 4 micrograms/ml, more than 90% of isolates were inhibited by trospectomycin. Overall, strains that produced beta-lactamase (n = 41) were more resistant to trospectomycin, penicillin G, cefoxitin, piperacillin, and tetracycline but not to clindamycin. In this study, trospectomycin had excellent in vitro activity against oral pigmented Bacteroides species.
将壮观霉素对97株口腔色素拟杆菌临床分离株的体外活性与其他五种抗菌药物的活性进行了比较。在4微克/毫升时,超过90%的分离株被壮观霉素抑制。总体而言,产生β-内酰胺酶的菌株(n = 41)对壮观霉素、青霉素G、头孢西丁、哌拉西林和四环素的耐药性更强,但对克林霉素不耐药。在本研究中,壮观霉素对口腔色素拟杆菌具有优异的体外活性。