喹诺酮类药物对社区医院分离出的厌氧菌的比较活性。
Comparative activity of the quinolones against anaerobic bacteria isolated at community hospitals.
作者信息
Goldstein E J, Citron D M
出版信息
Antimicrob Agents Chemother. 1985 Apr;27(4):657-9. doi: 10.1128/AAC.27.4.657.
Abstract
The in vitro activity of five quinolone compounds, amoxicillin, and clindamycin against 118 strains of anaerobic bacteria isolated at community hospitals was determined by an agar dilution method. Nalidixic acid and cinoxacin had poor activity, and norfloxacin and enoxacin showed relatively poor activity. Ciprofloxacin was active against Bacteroides fragilis, Fusobacterium species, Clostridium perfringens, and gram-positive cocci. At peak levels achievable in the feces, norfloxacin and enoxacin had moderate activity.
摘要
采用琼脂稀释法测定了5种喹诺酮类化合物、阿莫西林和克林霉素对社区医院分离出的118株厌氧菌的体外活性。萘啶酸和西诺沙星活性较差，诺氟沙星和依诺沙星活性相对较弱。环丙沙星对脆弱拟杆菌、梭杆菌属、产气荚膜梭菌和革兰氏阳性球菌有活性。在粪便中可达到的峰值水平时，诺氟沙星和依诺沙星具有中等活性。
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