Imray C H, Newbold K M, Davis A, Lavelle-Jones M, Neoptolemos J P
University Department of Surgery, Dudley Road Hospital, Birmingham, UK.
Eur J Surg Oncol. 1992 Aug;18(4):373-8.
The Golden Syrian hamster, which has a bile acid profile similar to that of humans, is often used as an experimental model for cholangiocarcinoma. Unfortunately, most chemical carcinogens result in other tumour types also being induced which can be disadvantageous. In the present study, we describe the development of cholangiocarcinoma associated with precursor lesions of bile duct proliferation and dysplasia which occurred following a single i.v. dose of methylazoxymethyl acetate (10, 20 or 40 mg/kg body weight). Moreover, no other tumours were induced. This model may, therefore, prove useful in investigating the steps involved in the carcinogenesis of cholangiocarcinoma.
金黄叙利亚仓鼠的胆汁酸谱与人类相似，常被用作胆管癌的实验模型。不幸的是，大多数化学致癌物会诱导产生其他类型的肿瘤，这可能不利。在本研究中，我们描述了在静脉注射单剂量乙酸甲基偶氮甲醇（10、20或40毫克/千克体重）后发生的与胆管增生和发育异常等前体病变相关的胆管癌的发展情况。此外，未诱导出其他肿瘤。因此，该模型可能有助于研究胆管癌发生过程中所涉及的步骤。
