Lee J H, Rim H J, Bak U B
Department of Parasitology, College of Medicine, Korea University, Seoul.
Korean J Parasitol. 1993 Mar;31(1):21-30. doi: 10.3347/kjp.1993.31.1.21.
The study was carried out to observe the effects of Clonorchis sinensis infection on induction of cholangiocarcinoma in Syrian golden hamsters to which 15 ppm dimethylnitrosamine (DMN) solution was administered for 8 weeks. The histopathological changes of the bile duct and liver cells were observed at the 11th week. In six of 8 hamsters (75%) which were treated with DMN and then infected with C. sinensis, the livers developed cholangiocarcinoma at 10 weeks after the infestation of C. sinensis. The features of cholangiocarcinoma lesions were adenomatous or papillary hyperplasia of the bile duct epithelia showing distinct anaplastic changes with mucinous cell metaplasia and necrotic area. In the hamsters which received either DMN or C. sinensis alone, the livers showed only hyperplastic changes of the bile duct epithelial cells. It was suggested that C. sinensis infection and DMN administration could be a synergism on the development of cholangiocarcinoma in Syrian golden hamsters.
本研究旨在观察华支睾吸虫感染对叙利亚金仓鼠胆管癌诱导的影响，这些仓鼠被给予15 ppm的二甲基亚硝胺（DMN）溶液，持续8周。在第11周观察胆管和肝细胞的组织病理学变化。在8只先用DMN处理然后感染华支睾吸虫的仓鼠中，有6只（75%）在感染华支睾吸虫10周后肝脏发生了胆管癌。胆管癌病变的特征是胆管上皮的腺瘤样或乳头状增生，表现出明显的间变改变，伴有黏液细胞化生和坏死区域。在仅接受DMN或华支睾吸虫感染的仓鼠中，肝脏仅表现出胆管上皮细胞的增生性变化。提示华支睾吸虫感染和DMN给药可能对叙利亚金仓鼠胆管癌的发生具有协同作用。
