Davydova I G, Kassil' V L, Raĭkhlin N T, Filippova N A
Biull Eksp Biol Med. 1992 Apr;113(4):352-5.
23 patients with malignant tumors of different location and histogenesis were investigated. There were no metastases in 9 cases. 10 patients had metastases in regional areas and 4--distant. The results were compared with those obtained in 4 patients with nonmalignant diseases. EEG, blood gases, plasma acid--base balance and ultrastructure of erythrocytes were explored before and after intravenous infusion of 4.2% sodium bicarbonate solution. The metabolic alkalosis induced amelioration of EEG, which was changed basically, the condense of pre-membrane layer disappeared or decreased in erythrocytes, and disaggregation of erythrocytes took place in cancer patients vs those with nonmalignant tumors. The results confirm the suggestion of generalized intracellular acidosis in malignant tumor patients. This acidosis can be temporarily avoided or diminished artificially by blood alkalosis.
对23例不同部位和组织发生的恶性肿瘤患者进行了研究。9例无转移。10例患者有区域淋巴结转移，4例有远处转移。将结果与4例非恶性疾病患者的结果进行比较。在静脉输注4.2%碳酸氢钠溶液前后，对脑电图、血气、血浆酸碱平衡和红细胞超微结构进行了研究。代谢性碱中毒使脑电图改善，基本恢复正常，癌症患者红细胞前膜层浓缩消失或减少，红细胞出现解聚，而非恶性肿瘤患者则无此现象。结果证实了恶性肿瘤患者存在全身性细胞内酸中毒的观点。这种酸中毒可通过血液碱化人为地暂时避免或减轻。
