Davydova I G, Kassil' V L, Filippova N A, Barinov M V
Vestn Ross Akad Med Nauk. 1995(4):24-5.
The authors examined 40 patients with malignant tumors of various histogenesis, sites and extent, as well as 5 patients with benign tumors and other non-tumorous diseases. They also studied their electroencephalography and peripheral blood lymphocytic and erythrocytic ultrastructure in metabolic alkalosis temporarily induced by intravenous sodium hydrogen carbonate. In cancer patients without late metastases, alkalosis caused a transient normalization of previously altered electroencephalography, erythrocyte disaggregation and substantially reduced the count of killer cells in small and middle lymphocytes. These findings suggest that patients with malignant neoplasms have a generalized intracellular acidosis which can be temporarily abolished by plasma alkalinization.
作者检查了40例具有各种组织发生、部位和范围的恶性肿瘤患者，以及5例患有良性肿瘤和其他非肿瘤性疾病的患者。他们还研究了这些患者在静脉注射碳酸氢钠暂时诱发代谢性碱中毒时的脑电图以及外周血淋巴细胞和红细胞的超微结构。在没有晚期转移的癌症患者中，碱中毒导致先前改变的脑电图短暂恢复正常，红细胞解聚，并显著减少了小淋巴细胞和中淋巴细胞中的杀伤细胞数量。这些发现表明，恶性肿瘤患者存在全身性细胞内酸中毒，血浆碱化可暂时消除这种酸中毒。
