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禽Ty-1轮状病毒与猿猴RRV轮状病毒之间新型重配病毒的分离与鉴定

Isolation and characterization of a novel reassortant between avian Ty-1 and simian RRV rotaviruses.

作者信息

Kool D A, Matsui S M, Greenberg H B, Holmes I H

机构信息

School of Microbiology, University of Melbourne, Parkville, Victoria, Australia.

出版信息

J Virol. 1992 Nov;66(11):6836-9. doi: 10.1128/JVI.66.11.6836-6839.1992.

DOI:10.1128/JVI.66.11.6836-6839.1992
PMID:1328691
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC240188/
Abstract

A reassortant, TyRh, was isolated after coinfection of MA104 cells with avian Ty-1 and simian RRV rotaviruses. Hybridization and serological studies showed that the reassortant's 4th gene, which encodes Vp4, was derived from the simian RRV rotavirus parent, whereas the remaining 10 genes were derived from the avian Ty-1 rotavirus parent.

摘要

在MA104细胞被禽Ty-1轮状病毒和猿猴RRV轮状病毒共同感染后，分离出了一种重配病毒TyRh。杂交和血清学研究表明，重配病毒编码Vp4的第4个基因来源于猿猴RRV轮状病毒亲本，而其余10个基因则来源于禽Ty-1轮状病毒亲本。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a078/240188/fced8f3feca5/jvirol00042-0607-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a078/240188/de496370658a/jvirol00042-0607-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a078/240188/fced8f3feca5/jvirol00042-0607-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a078/240188/de496370658a/jvirol00042-0607-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a078/240188/fced8f3feca5/jvirol00042-0607-b.jpg

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本文引用的文献

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Production and preliminary characterization of monoclonal antibodies directed at two surface proteins of rhesus rotavirus.针对恒河猴轮状病毒两种表面蛋白的单克隆抗体的制备及初步特性分析
J Virol. 1983 Aug;47(2):267-75. doi: 10.1128/JVI.47.2.267-275.1983.
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Identification of the rotaviral gene that codes for hemagglutination and protease-enhanced plaque formation.
利用整合素的轮状病毒通过VP4 DGE序列与α2β1整合素α2 I结构域结合，并在细胞进入过程中利用VP7识别αXβ2和αVβ3。
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Interactions between the two surface proteins of rotavirus may alter the receptor-binding specificity of the virus.轮状病毒的两种表面蛋白之间的相互作用可能会改变病毒的受体结合特异性。
J Virol. 1996 Feb;70(2):1218-22. doi: 10.1128/JVI.70.2.1218-1222.1996.
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Preferential selection of VP7 gene from a parent rotavirus strain (SA11) in sequential passages after mixed infection with SA11 and SA11-human rotavirus single-VP7 gene-substitution reassortants.在与SA11和SA11-人轮状病毒单VP7基因替代重配体混合感染后的连续传代中，从亲本轮状病毒株（SA11）中优先选择VP7基因。
Arch Virol. 1995;140(4):775-81. doi: 10.1007/BF01309965.
鉴定编码血凝和蛋白酶增强蚀斑形成的轮状病毒基因。
Virology. 1983 Feb;125(1):194-205. doi: 10.1016/0042-6822(83)90073-9.
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