Borkow G, Ovadia M
Department of Zoology, George S. Wise Faculty of Life Sciences Tel Aviv University, Ramat Aviv, Israel.
Life Sci. 1992;51(16):1261-7. doi: 10.1016/0024-3205(92)90015-h.
Viperid, elapid and crotalid snake venoms were screened in vitro for antiviral activity against Sendai virus. The hemolysis of 10(8) human erythrocytes in 1 ml, caused by 70 HAU of Sendai virus, was abolished when the virions were pretreated with 10 ug of the viperid venom of Echis coloratus, and was considerably diminished when pretreated with 10 ug of the venom of Echis carinatus sochureki, the cobra venoms of Naja atra and Naja nigricollis nigricollis. These venoms did not affect the erythrocytes but inhibited the virions themselves irreversibly. All other examined snake venoms had low or no antiviral activity. There was no correlation between the proteolytic and the antiviral activity of the venoms.
对蝰蛇科、眼镜蛇科和响尾蛇科蛇毒进行了体外抗仙台病毒活性筛选。当用10微克锯鳞蝰蛇毒预处理病毒粒子时，由70个血凝单位的仙台病毒引起的1毫升中10⁸个人类红细胞的溶血被消除，而当用10微克锯鳞蝰蛇（索氏亚种）、中华眼镜蛇和黑颈眼镜蛇的蛇毒预处理时，溶血则显著减少。这些蛇毒不影响红细胞，但能不可逆地抑制病毒粒子本身。所有其他检测的蛇毒抗病毒活性较低或无抗病毒活性。蛇毒的蛋白水解活性和抗病毒活性之间没有相关性。
