Fragoso Y D, Skinner E R
Department of Molecular and Cell Biology, University of Aberdeen, Marischal College, U.K.
Biochem Pharmacol. 1992 Sep 25;44(6):1085-90. doi: 10.1016/0006-2952(92)90371-o.
The effect of dietary supplementation with evening primrose oil (containing 70% gammalinolenic acid) on the concentration of plasma lipids and lipoproteins of the New Zealand White rabbit was investigated. No significant changes were observed in the concentrations of plasma cholesterol or triglycerides during the treatment, although an increase in high density lipoprotein (HDL) cholesterol (P < 0.01) was observed at 4 weeks of evening primrose oil intake and 2 weeks after withdrawal. However, when HDL subpopulations were resolved by gradient gel electrophoresis, major alterations were observed in the distribution of HDL subfractions. These included an increase in HDL2b (P < 0.001) and HDL3c (P < 0.001) and the appearance of very large particles of HDL. These findings suggest that supplementation of diets with n-6 fatty acids may be effective in the long-term prevention of atherosclerosis.
研究了日粮添加月见草油（含70%γ-亚麻酸）对新西兰白兔血浆脂质和脂蛋白浓度的影响。在治疗期间，血浆胆固醇或甘油三酯浓度未观察到显著变化，尽管在摄入月见草油4周时和停药后2周观察到高密度脂蛋白（HDL）胆固醇增加（P<0.01）。然而，当通过梯度凝胶电泳分离HDL亚群时，观察到HDL亚组分分布有主要变化。这些变化包括HDL2b增加（P<0.001）和HDL3c增加（P<0.001）以及出现非常大的HDL颗粒。这些发现表明，日粮中添加n-6脂肪酸可能对动脉粥样硬化的长期预防有效。
