Ishikawa T, Fujiyama Y, Igarashi O, Morino M, Tada N, Kagami A, Sakamoto T, Nagano M, Nakamura H
Department of Internal Medicine, Aoto Hospital, Jikei Medical University, Tokyo, Japan.
Atherosclerosis. 1989 Feb;75(2-3):95-104. doi: 10.1016/0021-9150(89)90165-2.
Nineteen hypercholesterolemic patients (10 without and 9 with hypertriglyceridemia) were given evening primrose oil rich in gammalinolenic acid (GLA, 18: 3n - 6), in a placebo controlled cross-over design, over 16 weeks (8 + 8 weeks), with safflower oil as the placebo. During supplementation with evening primrose oil, dihomogammalinolenic acid (20: 3n - 6) increased in plasma lipids and red blood cells, and in subjects without hypertriglyceridemia there was a significant decrease in low density lipoprotein-cholesterol and plasma apolipoprotein B compared with the levels observed during safflower oil administration. Our results confirmed that evening primrose oil is effective in lowering low density lipoprotein in hypercholesterolemic patients.
19名高胆固醇血症患者（10名无高甘油三酯血症，9名有高甘油三酯血症）参与了一项安慰剂对照的交叉试验，以富含γ-亚麻酸（GLA，18:3n-6）的月见草油为试验药物，红花油为安慰剂，给药期共16周（8+8周）。在补充月见草油期间，血浆脂质和红细胞中的二高γ-亚麻酸（20:3n-6）增加，并且在无高甘油三酯血症的受试者中，与服用红花油期间观察到的水平相比，低密度脂蛋白胆固醇和血浆载脂蛋白B显著降低。我们的结果证实，月见草油对降低高胆固醇血症患者的低密度脂蛋白有效。
