单剂量阿奇霉素和多西环素治疗男性衣原体尿道炎的双盲研究。
A double blind study of single dose azithromycin and doxycycline in the treatment of chlamydial urethritis in males.
作者信息
Nilsen A, Halsos A, Johansen A, Hansen E, Tørud E, Moseng D, Anestad G, Størvold G
机构信息
Department of Dermatovenerology, University of Bergen, Norway.
出版信息
Genitourin Med. 1992 Oct;68(5):325-7. doi: 10.1136/sti.68.5.325.
OBJECTIVE
To compare the efficacy and safety of azithromycin and doxycycline in the treatment of males with uncomplicated urethritis caused by chlamydia trachomatis.
DESIGN
A multicentre, double-blind, randomised treatment study.
SUBJECTS
130 male outpatients with clinical signs and symptoms of urethritis.
SETTING
STD clinics at four Norwegian University Hospitals.
METHODS
Patients were randomly allocated to 1000 mg azithromycin as single dose or doxycycline 100 mg twice daily for 7 days. Clinical, bacteriological and safety assessments were made at entry and after 1 and 2 weeks. Safety data were also repeated after 4 weeks.
RESULTS
Demographic data were similar in both groups. At the week 1 assessment bacteriological eradication was achieved in 44 of 44 evaluable azithromycintreated patients and in 42 of 42 in the doxycycline group. At the week 2 assessment the corresponding figures were 35 of 35 and 34 of 34 respectively.
CONCLUSION
Azithromycin 1000 mg single dose was as effective as doxycycline 100 mg twice daily for 7 days in male patients with chlamydial urethritis.
目的
比较阿奇霉素和多西环素治疗男性沙眼衣原体所致单纯性尿道炎的疗效和安全性。
设计
一项多中心、双盲、随机治疗研究。
研究对象
130例有尿道炎临床症状和体征的男性门诊患者。
研究地点
挪威4所大学医院的性传播疾病诊所。
方法
患者被随机分配接受1000mg阿奇霉素单剂量治疗或多西环素100mg每日2次共7天的治疗。在入组时以及1周和2周后进行临床、细菌学和安全性评估。4周后也重复收集安全性数据。
结果
两组的人口统计学数据相似。在第1周评估时，44例可评估的接受阿奇霉素治疗的患者中有44例实现细菌学清除，多西环素组42例中有42例实现细菌学清除。在第2周评估时，相应数字分别为35例中的35例和34例中的34例。
结论
对于衣原体尿道炎男性患者，1000mg单剂量阿奇霉素与100mg多西环素每日2次共7天的疗效相当。
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