单次口服1.0克阿奇霉素治疗衣原体宫颈炎后宫颈黏液和血浆中的阿奇霉素水平。
Azithromycin levels in cervical mucus and plasma after a single 1.0g oral dose for chlamydial cervicitis.
作者信息
Worm A M, Osterlind A
机构信息
Department of Dermato-Venereology, Bispebjerg Hospital, Copenhagen NV, Denmark.
出版信息
Genitourin Med. 1995 Aug;71(4):244-6. doi: 10.1136/sti.71.4.244.
Abstract
OBJECTIVE
To determine the kinetics of azithromycin in cervical mucus and plasma.
SUBJECTS AND METHODS
Azithromycin concentrations were determined in plasma and mucus samples from 20 women with cervical chlamydial infection one, seven and fourteen days after a single oral 1.0 g dose.
RESULTS
In mucus, all measurable azithromycin concentrations were above the minimal inhibitory concentration against Chlamydia trachomatis on day 7 as well as on day 14.
CONCLUSION
The high cervical mucus concentrations of azithromycin can explain the high clinical and microbiological efficacy.
摘要
目的
确定阿奇霉素在宫颈黏液和血浆中的动力学。
受试者与方法
对20例宫颈衣原体感染女性单次口服1.0 g剂量后1天、7天和14天采集的血浆和黏液样本中的阿奇霉素浓度进行测定。
结果
在黏液中，第7天和第14天所有可测的阿奇霉素浓度均高于沙眼衣原体的最低抑菌浓度。
结论
阿奇霉素在宫颈黏液中的高浓度可解释其较高的临床和微生物学疗效。
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本文引用的文献
1
Preferential concentration of azithromycin in an infected mouse thigh model.
J Antimicrob Chemother. 1993 Jun;31 Suppl E:5-16. doi: 10.1093/jac/31.suppl_e.5.
2
Selection of dose regimens of azithromycin .阿奇霉素给药方案的选择。
J Antimicrob Chemother. 1993 Jun;31 Suppl E:39-50. doi: 10.1093/jac/31.suppl_e.39.
3
Comparison of azithromycin and doxycycline in the treatment of non-gonococcal urethritis in men.阿奇霉素与多西环素治疗男性非淋菌性尿道炎的比较
J Antimicrob Chemother. 1993 Jun;31 Suppl E:185-92. doi: 10.1093/jac/31.suppl_e.185.
4
Single-dose oral azithromycin versus seven-day doxycycline in the treatment of non-gonococcal urethritis in males.单剂量口服阿奇霉素与七天服用强力霉素治疗男性非淋菌性尿道炎的比较。
J Antimicrob Chemother. 1993 Jun;31 Suppl E:177-83. doi: 10.1093/jac/31.suppl_e.177.
5
Comparison of azithromycin, roxithromycin, and cephalexin penetration kinetics in early and mature abscesses.
J Antimicrob Chemother. 1993 Jun;31 Suppl E:17-28. doi: 10.1093/jac/31.suppl_e.17.
6
Single dose azithromycin treatment of gonorrhea and infections caused by C. trachomatis and U. urealyticum in men.单剂量阿奇霉素治疗男性淋病以及沙眼衣原体和解脲脲原体引起的感染。
Sex Transm Dis. 1994 Jan-Feb;21(1):43-6. doi: 10.1097/00007435-199401000-00009.
7
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8
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9
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J Antimicrob Chemother. 1990 Jan;25 Suppl A:1-5. doi: 10.1093/jac/25.suppl_a.1.
10
Antibiotic prescribing practices and patient compliance in the community.
Scand J Infect Dis Suppl. 1992;83:7-14.
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