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单次口服1.0克阿奇霉素治疗衣原体宫颈炎后宫颈黏液和血浆中的阿奇霉素水平。

Azithromycin levels in cervical mucus and plasma after a single 1.0g oral dose for chlamydial cervicitis.

作者信息

Worm A M, Osterlind A

机构信息

Department of Dermato-Venereology, Bispebjerg Hospital, Copenhagen NV, Denmark.

出版信息

Genitourin Med. 1995 Aug;71(4):244-6. doi: 10.1136/sti.71.4.244.

DOI:10.1136/sti.71.4.244
PMID:7590717
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1195522/
Abstract

OBJECTIVE

To determine the kinetics of azithromycin in cervical mucus and plasma.

SUBJECTS AND METHODS

Azithromycin concentrations were determined in plasma and mucus samples from 20 women with cervical chlamydial infection one, seven and fourteen days after a single oral 1.0 g dose.

RESULTS

In mucus, all measurable azithromycin concentrations were above the minimal inhibitory concentration against Chlamydia trachomatis on day 7 as well as on day 14.

CONCLUSION

The high cervical mucus concentrations of azithromycin can explain the high clinical and microbiological efficacy.

摘要

目的

确定阿奇霉素在宫颈黏液和血浆中的动力学。

受试者与方法

对20例宫颈衣原体感染女性单次口服1.0 g剂量后1天、7天和14天采集的血浆和黏液样本中的阿奇霉素浓度进行测定。

结果

在黏液中，第7天和第14天所有可测的阿奇霉素浓度均高于沙眼衣原体的最低抑菌浓度。

结论

阿奇霉素在宫颈黏液中的高浓度可解释其较高的临床和微生物学疗效。

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Selection of dose regimens of azithromycin .阿奇霉素给药方案的选择。
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The pharmacokinetics of azithromycin in human serum and tissues.阿奇霉素在人血清和组织中的药代动力学。
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