Studdert V P, Hughes K L
Veterinary Clinic and Hospital, School of Veterinary Science, University of Melbourne, Werribee, Victoria, Australia.
J Am Vet Med Assoc. 1992 Nov 1;201(9):1388-90.
Marked improvement was observed in the condition of 6 cats with opportunistic mycobacterial infections during treatment with enrofloxacin, a fluoroquinolone antibiotic. Complete remission was achieved in 3 cats after 3 to 7 weeks of treatment. The other 3 cats were euthanatized after 1 to 2 weeks of treatment for reasons not related to the treatment. Lesions did not recur within the follow-up period, which ranged from 9 to 16 months. Treatment of opportunistic mycobacterial infection in cats is complicated because many mycobacteria are resistant to antituberculosis drugs, which also can be toxic to cats, and because results of susceptibility testing with other antimicrobials do not always correlate with clinical response. Often, neither satisfactory nor long-term response is observed in cats treated surgically or with the antibiotics currently recommended. These findings suggested that enrofloxacin is effective in the treatment of infections caused by Mycobacterium smegmatis and M fortuitum var fortuitum in cats.
在用氟喹诺酮类抗生素恩诺沙星治疗期间，6只患有机会性分枝杆菌感染的猫的病情有明显改善。3只猫在治疗3至7周后完全缓解。另外3只猫在治疗1至2周后因与治疗无关的原因实施了安乐死。在9至16个月的随访期内病变未复发。猫的机会性分枝杆菌感染治疗很复杂，因为许多分枝杆菌对抗结核药物耐药，而这些药物对猫也可能有毒，并且因为用其他抗菌药物进行药敏试验的结果并不总是与临床反应相关。通常，接受手术治疗或使用目前推荐的抗生素治疗的猫，既未观察到令人满意的反应，也未观察到长期反应。这些发现表明，恩诺沙星对治疗猫由耻垢分枝杆菌和偶然分枝杆菌偶然亚种引起的感染有效。
