Levine P H, Ablashi D V, Saxinger W C, Connelly R R
Environmental Epidemiology Branch, National Institutes of Health, Bethesda, MD 20892.
Leukemia. 1992 Nov;6(11):1229-31.
Human herpesvirus-6 (HHV-6), a ubiquitous virus that causes exanthem subitum and occasional cases of infectious mononucleosis, hepatitis and other viral syndromes, has also been associated with acute lymphocytic leukemia (ALL) in children. To further investigate this association, we obtained sera from 50 patients with ALL and 50 age-sex matched controls. Antibodies to HHV-6 were determined using ELISA and indirect immunofluorescent antibody (IFA) tests. No significant difference between antibody titers in the cases and controls was observed. Since seroepidemiologic studies have demonstrated higher HHV-6 antibody titers in young children than in adults, this serologic study suggests that the previous association reported for HHV-6 and ALL was a result of the age of the population rather than a relationship between the virus and the disease.
人疱疹病毒6型（HHV-6）是一种普遍存在的病毒，可引起幼儿急疹以及偶尔的传染性单核细胞增多症、肝炎和其他病毒综合征病例，它还与儿童急性淋巴细胞白血病（ALL）有关。为了进一步研究这种关联，我们从50例ALL患者和50例年龄及性别匹配的对照者中获取了血清。使用酶联免疫吸附测定（ELISA）和间接免疫荧光抗体（IFA）试验检测HHV-6抗体。病例组和对照组的抗体滴度未观察到显著差异。由于血清流行病学研究表明幼儿的HHV-6抗体滴度高于成年人，这项血清学研究表明，先前报道的HHV-6与ALL之间的关联是人群年龄的结果，而非病毒与疾病之间的关系。
