Section of Hematology. Department of Oncology, Hematology and Respiratory Diseases. Azienda Ospedaliero-Universitaria di Modena- Policlinico, Modena Italy.
Mediterr J Hematol Infect Dis. 2011;3(1):e2011043. doi: 10.4084/MJHID.2011.043. Epub 2011 Oct 24.
Similarly to Epstein-Barr virus (EBV), the human herpesvirus-8 (HHV-8) is a γ-herpesvirus, recently recognized to be associated with the occurrence of rare B cell lymphomas and atypical lymphoproliferations, especially in the human immunodeficiency virus (HIV) infected subjects. Moreover, the human herpesvirus-6 (HHV-6), a β-herpesvirus, has been shown to be implicated in some non-malignant lymph node proliferations, such as the Rosai Dorfman disease, and in a proportion of Hodgkin's lymphoma cases. HHV-6 has a wide cellular tropism and it might play a role in the pathogenesis of a wide variety of human diseases, but given its ubiquity, disease associations are difficult to prove and its role in hematological malignancies is still controversial. The involvement of another β-herpesvirus, the human cytomegalovirus (HCMV), has not yet been proven in human cancer, even though recent findings have suggested its potential role in the development of CD4(+) large granular lymphocyte (LGL) lymphocytosis. Here, we review the current knowledge on the pathogenetic role of HHV-8 and human β-herpesviruses in human lymphoproliferative disorders.
类似于 Epstein-Barr 病毒（EBV），人类疱疹病毒-8（HHV-8）是一种 γ-疱疹病毒，最近被认为与罕见的 B 细胞淋巴瘤和非典型淋巴增生有关，特别是在人类免疫缺陷病毒（HIV）感染的患者中。此外，β-疱疹病毒人类疱疹病毒-6（HHV-6）已被证明与一些非恶性淋巴结增生有关，如 Rosai Dorfman 病，以及一部分霍奇金淋巴瘤病例。HHV-6 具有广泛的细胞嗜性，可能在多种人类疾病的发病机制中发挥作用，但由于其普遍存在，疾病相关性难以证明，其在血液系统恶性肿瘤中的作用仍存在争议。另一种β-疱疹病毒人类巨细胞病毒（HCMV）在人类癌症中的作用尚未得到证实，尽管最近的研究结果表明其在 CD4(+) 大颗粒淋巴细胞（LGL）淋巴增生症的发展中可能具有潜在作用。在这里，我们回顾了 HHV-8 和人类β-疱疹病毒在人类淋巴增生性疾病中的发病机制作用的现有知识。
