Wang X, Fu X, Hoffman R M
AntiCancer, Inc., San Diego, California 92110.
Anticancer Res. 1992 Sep-Oct;12(5):1399-401.
A new nude-mouse metastasizing orthotopic transplant model of human adenocarcinoma of the lung is described. Histologically-intact human A549 adenocarcinoma lung tumors were transplanted to the left lung of nude mice via a thoracotomy procedure we have developed. The transplanted tumors grew extensively locally and metastasized to the opposite lung, lymph nodes and other clinically-relevant sites. The results described indicate the model developed could have clinical relevance and contrast with models of the A549 lung adenocarcinoma constructed orthotopically with injections of cell suspensions which result in low metastatic potential.
本文描述了一种新的人肺腺癌裸鼠原位转移移植模型。通过我们开发的开胸手术，将组织学完整的人A549肺腺癌肿瘤移植到裸鼠的左肺。移植的肿瘤在局部广泛生长，并转移至对侧肺、淋巴结和其他临床相关部位。所述结果表明，所开发的模型可能具有临床相关性，与通过注射细胞悬液原位构建的A549肺腺癌模型形成对比，后者转移潜力较低。
