新型合成微管抑制剂诺考达唑对脊髓上背角组织化学结构的跨神经节效应。
Transganglionic effects of Nocodazole, a new synthetic microtubule inhibitor, upon the histochemical structure of the spinal upper dorsal horn.
作者信息
Porubcsanszki Z, Csillik B
机构信息
Department of Anatomy, Albert Szent-Györgyi Medical University, Szeged, Hungary.
出版信息
J Hirnforsch. 1992;33(2):169-71.
PMID:1333003
Abstract
Perineural application of Nocodazole (R 17934 of Janssen Pharmaceutica), a new synthetic microtubule inhibitor, induces transganglionic degenerative atrophy of central terminals in the spinal cord of the inflicted primary sensory neurons. This drug offers new possibilities for clinical trials aiming to relieve chronic pain by subcutaneous injection of a microtubule inhibitor.
摘要
新型合成微管抑制剂诺考达唑（杨森制药公司的R 17934）经神经周围给药，可导致受影响的初级感觉神经元脊髓中枢终末发生跨神经节变性萎缩。这种药物为旨在通过皮下注射微管抑制剂来缓解慢性疼痛的临床试验提供了新的可能性。
Zotero 插件