Gaggero A, Avendaño L F, Fernández J, Spencer E
Departamento de Microbiología y Parasitología, Facultad de Medicina, Santiago, Chile.
J Clin Microbiol. 1992 Dec;30(12):3294-7. doi: 10.1128/jcm.30.12.3294-3297.1992.
We studied the transmission of rotavirus (RV) in 950 patients under 2 years of age hospitalized for diarrhea in Santiago, Chile. Stool samples were collected every other day from all patients during their entire hospital stay. To trace nosocomial transmission, we mapped the ward at the time of detection of RV. Comparative study by polyacrylamide gel electrophoresis of 315 RV isolates (180 detected upon admission of patients and 135 attributed to nosocomial transmission) allowed the identification of 18 different electropherotypes. An electropherotype similar to that of a community-acquired case was found in the same room in 81% of nosocomial cases and in the ward in 92% of nosocomial cases. It was concluded that the infants admitted shedding RV are the major source of nosocomial transmission and there was not a RV strain that was particularly transmissible.
我们对智利圣地亚哥950名2岁以下因腹泻住院的患者进行了轮状病毒（RV）传播情况的研究。在所有患者住院期间，每隔一天采集粪便样本。为追踪医院内传播情况，我们在检测到RV时绘制了病房分布图。通过对315株RV分离株（180株在患者入院时检测到，135株归因于医院内传播）进行聚丙烯酰胺凝胶电泳的对比研究，鉴定出18种不同的电泳型。在81%的医院内感染病例中，同一房间发现了与社区获得性病例电泳型相似的情况，在92%的医院内感染病例中，病房内发现了这种情况。得出的结论是，入院时已排出RV的婴儿是医院内传播的主要来源，且不存在特别容易传播的RV毒株。
