Borisch B, Hennig I, Horber F, Bürki K, Laissue J
Institute of Pathology, University of Berne, Switzerland.
Virchows Arch A Pathol Anat Histopathol. 1992;421(5):443-7. doi: 10.1007/BF01606918.
The clinical and histological findings in a 54-year-old patient with enteropathy-associated T-cell lymphoma (EATL) occurring 18 years after renal transplantation are presented. Ten years after adult-onset coeliac disease the patient developed medium to large T-cell non-Hodgkin's lymphoma of the small intestine. Epstein-Barr virus (EBV) genome was detected by polymerase chain reaction in the lymphoma tissue and localized via Epstein-Barr virus RNAs in situ hybridization to some of the tumour cells. This is the first case report of EBV-positive EATL occurring in the setting of immunosuppression.
本文报告了一名54岁患者的临床和组织学检查结果，该患者在肾移植18年后发生了肠病相关T细胞淋巴瘤（EATL）。在成人起病的乳糜泻10年后，该患者发展为小肠中到大细胞T细胞非霍奇金淋巴瘤。通过聚合酶链反应在淋巴瘤组织中检测到爱泼斯坦-巴尔病毒（EBV）基因组，并通过爱泼斯坦-巴尔病毒RNA原位杂交在一些肿瘤细胞中定位。这是免疫抑制情况下发生的EBV阳性EATL的首例病例报告。
