Borisch B, Finke J, Hennig I, Delacrétaz F, Schneider J, Heitz P U, Laissue J A
Institute of Pathology, Bern, Switzerland.
J Pathol. 1992 Oct;168(2):229-36. doi: 10.1002/path.1711680212.
Tissue samples of 21 HIV-positive patients have been studied for the presence and distribution of Epstein-Barr virus (EBV) subtypes A and B. This was done by PCR, EBER in situ hybridization, and immunohistochemical detection of EBV latent membrane protein (LMP) in AIDS-associated malignant lymphomas (16 cases) and lymphatic organs of patients without lymphoma (5 cases). Eleven cases were considered to be EBV-positive, with type A in four, and type B virus in four other cases. In patients with malignant lymphoma, EBV was localized in tumour tissue exclusively. One patient without lymphoma presented with multiple EBV genome type B-positive cells in all the lymphoid tissue samples examined. In HIV-positive patients, both subtypes of EBV, A and B, may play a role in the pathogenesis of lymphoproliferative lesions.
对21例HIV阳性患者的组织样本进行了研究，以检测爱泼斯坦-巴尔病毒（EBV）A和B亚型的存在及分布情况。研究方法包括聚合酶链反应（PCR）、EBER原位杂交以及对艾滋病相关恶性淋巴瘤（16例）和无淋巴瘤患者淋巴器官（5例）进行EBV潜伏膜蛋白（LMP）的免疫组化检测。11例被认为是EBV阳性，其中4例为A型，另外4例为B型病毒。在恶性淋巴瘤患者中，EBV仅定位于肿瘤组织。1例无淋巴瘤患者在所有检测的淋巴组织样本中均出现多个EBV基因组B型阳性细胞。在HIV阳性患者中，EBV的A和B两种亚型可能在淋巴增殖性病变的发病机制中发挥作用。
