Pinkston J A, Cole P
Gordon L. Ross Cancer Center, Princeton Baptist Medical Center, Birmingham, AL., USA.
Am J Epidemiol. 1996 Jul 15;144(2):183-7. doi: 10.1093/oxfordjournals.aje.a008906.
The etiology of Warthin's tumor, a benign parotid gland tumor, is unknown. Recent evidence suggests a possible relation with cigarette smoking as well as increasing incidence. We reviewed the medical record of subjects with a major salivary gland tumor newly diagnosed in Jefferson County, Alabama, from 1968 to 1989, and identified 149 Warthin's tumors. The 533 cases with other major salivary gland tumors were used as controls. The analysis showed that 96% of Warthin's tumors occurred in whites. The relative incidence of Warthin's tumor among smokers versus nonsmokers was 7.6 for men (95 percent confidence interval 3.2-18.3; p < 0.001) and 17.4 for women (95 percent confidence interval 6.5-54.7; p < 0.001). Smokers of both sexes with Warthin's tumor smoked more heavily than did those with other salivary gland tumors (p < 0.001). From 1968 through 1988, Warthin's tumors steadily increased in number and as a proportion of salivary gland tumors (males, p = 0.003; females, p = 0.008). We also observed a significant increase in the incidence rate for Warthin's tumor (p = 0.041) but not for other salivary gland tumors. We conclude that Warthin's tumor is strongly associated with cigarette smoking and that the incidence rate is increasing. The disease is rare in blacks.
沃辛瘤是一种腮腺良性肿瘤，其病因尚不清楚。最近的证据表明，它可能与吸烟有关，且发病率呈上升趋势。我们回顾了1968年至1989年在阿拉巴马州杰斐逊县新诊断出的主要涎腺肿瘤患者的病历，确定了149例沃辛瘤。将533例其他主要涎腺肿瘤病例用作对照。分析表明，96%的沃辛瘤发生在白人中。吸烟者与不吸烟者相比，男性沃辛瘤的相对发病率为7.6（95%置信区间3.2 - 18.3；p < 0.001），女性为17.4（95%置信区间6.5 - 54.7；p < 0.001）。患沃辛瘤的男女吸烟者比患其他涎腺肿瘤的吸烟者吸烟量更大（p < 0.001）。从1968年到1988年，沃辛瘤的数量及其占涎腺肿瘤的比例稳步上升（男性，p = 0.003；女性，p = 0.008）。我们还观察到沃辛瘤的发病率显著上升（p = 0.041），但其他涎腺肿瘤的发病率没有上升。我们得出结论，沃辛瘤与吸烟密切相关，且发病率在上升。该疾病在黑人中罕见。
