Roy P
Laboratory of Molecular Biophysics, Oxford University, UK.
Vet Microbiol. 1992 Nov;33(1-4):155-68. doi: 10.1016/0378-1135(92)90043-s.
Bluetongue virus-like and core-like structures consisting of multiproteins in different molar ratios, have been synthesized using baculovirus multiple expression vectors. These particles lacking genetic materials, mimic the single- and double-shelled authentic virus particles and have been shown to be highly immunogenic and protective for sheep challenged with infectious virus. The formation of virus-like particles, using this new technology, offers a novel approach to vaccine development.
利用杆状病毒多表达载体合成了由不同摩尔比的多蛋白组成的蓝舌病毒样结构和核心样结构。这些缺乏遗传物质的颗粒模拟了单壳和双壳的真实病毒颗粒，并已证明对感染病毒攻击的绵羊具有高度免疫原性和保护作用。使用这项新技术形成病毒样颗粒为疫苗开发提供了一种新方法。
