From genes to complex structures of bluetongue virus and their efficacy as vaccines.

Bluetongue virus-like and core-like structures consisting of multiproteins in different molar ratios, have been synthesized using baculovirus multiple expression vectors. These particles lacking genetic materials, mimic the single- and double-shelled authentic virus particles and have been shown to be highly immunogenic and protective for sheep challenged with infectious virus. The formation of virus-like particles, using this new technology, offers a novel approach to vaccine development.