Thiry E, Bublot M, Dubuisson J, Van Bressem M F, Lequarre A S, Lomonte P, Vanderplasschen A, Pastoret P P
Department of Virology-Immunology, Faculty of Veterinary Medicine, University of Liège, Belgium.
Vet Microbiol. 1992 Nov;33(1-4):79-92. doi: 10.1016/0378-1135(92)90037-t.
Bovine herpesvirus type 4 (BHV-4) is a ubiquitous virus of cattle. Its genome is a 144 +/- 6 kb double-stranded DNA consisting of a unique central part (L-DNA) flanked at both ends by tandem repeats called polyrepetitive DNA (prDNA or H-DNA). The overall arrangement of genes has been obtained by the analysis of homologies between short BHV-4 DNA sequences and corresponding genes of Epstein-Barr virus (EBV) and herpesvirus saimiri (HVS). The gene expression is temporally regulated. Glycoprotein precursor p (gp10/gp17) is expressed as gamma 1 polypeptide. Glycoproteins gp1, gp8, gp11 and their precursors are gamma 2 proteins. The analysis of strain variations allows the definition of two types of strains, based on the DNA patterns: the Movar 33/63-like and the DN 599-like strains. Only the M40 strain, isolated in India, fails to fit this classification. The genomic variations have been compiled to build a dendrogram showing three levels of divergence between BHV-4 strains or isolates. The available molecular data indicate that the BHV-4 genome shares much similarity with the DNA of EBV and HVS, two representative members of the gammaherpesvirinae. BHV-4 may therefore be classified in the subfamily gammaherpesvirinae.
牛疱疹病毒4型（BHV - 4）是一种在牛群中普遍存在的病毒。其基因组是一个144 +/- 6 kb的双链DNA，由一个独特的中央部分（L - DNA）组成，两端侧翼为串联重复序列，称为多重复DNA（prDNA或H - DNA）。通过分析BHV - 4短DNA序列与爱泼斯坦 - 巴尔病毒（EBV）和猴疱疹病毒（HVS）相应基因之间的同源性，已获得基因的总体排列。基因表达受到时间调控。糖蛋白前体p（gp10/gp17）作为γ1多肽表达。糖蛋白gp1、gp8、gp11及其前体是γ2蛋白。基于DNA模式对菌株变异的分析允许定义两种类型的菌株：Movar 33/63样菌株和DN 599样菌株。仅在印度分离出的M40菌株不符合这种分类。已汇编基因组变异以构建一个显示BHV - 4菌株或分离株之间三个分歧水平的树状图。现有的分子数据表明，BHV - 4基因组与γ疱疹病毒亚科的两个代表性成员EBV和HVS的DNA有许多相似之处。因此，BHV - 4可归类于γ疱疹病毒亚科。
