Moreno-Lopez J, Goltz M, Rehbinder C, Valsala K V, Ludwig H
Zentralbl Veterinarmed B. 1989 Sep;36(7):481-6. doi: 10.1111/j.1439-0450.1989.tb00633.x.
A herpesvirus was isolated from tumours of the ethmoidal mucosa in two of three head of cattle in the State of Kerala, India. The virus designated M40 was cytopathic for a variety of cultured bovine and porcine cells and it did not kill suckling mice or chicken embryos. Sera from tumour-bearing cattle and goats reacted with the M40 virus. Immunofluorescence tests with FITC-conjugated IgG from a bovine monospecific antiserum to bovine herpesvirus 4 (BHV-4) stained the M40 virus specific antigen in infected cells. Experimental infection of goats with the M40 virus did not result in development of tumours. This virus is therefore considered to represent a "passenger" virus. A great similarity was found between restriction patterns of DNAs extracted from M40 virus and the strain 66-P-347, a reference strain of the BHV-4 group.
在印度喀拉拉邦的三头牛中，有两头牛的筛窦粘膜肿瘤中分离出一种疱疹病毒。命名为M40的这种病毒对多种培养的牛和猪细胞具有细胞病变作用，并且它不会杀死乳鼠或鸡胚。患肿瘤的牛和山羊的血清与M40病毒发生反应。用来自牛抗牛疱疹病毒4（BHV - 4）单特异性抗血清的异硫氰酸荧光素（FITC）偶联的IgG进行免疫荧光试验，可对感染细胞中的M40病毒特异性抗原进行染色。用M40病毒对山羊进行实验性感染未导致肿瘤发生。因此，这种病毒被认为是一种“过客”病毒。从M40病毒中提取的DNA的限制性图谱与BHV - 4组的参考菌株66 - P - 347之间发现了很大的相似性。
