Arushanian E B, Ovanesov K B
Zh Vyssh Nerv Deiat Im I P Pavlova. 1991 Jul-Aug;41(4):822-7.
On the pinealectomized rats shifts of main parameters of forced swimming and its time course with increase of rhythmical depression index were observed. Pinealectomy also potentiated depressogenic effect of reserpine which was attenuated by melatonin. At the same time on this model pineal compounds (melatonin, peptides) after acute and chronic administration demonstrated their own antidepressant activity.
在松果体切除的大鼠中，观察到随着节律性抑郁指数的增加，强迫游泳的主要参数及其时间进程发生了变化。松果体切除还增强了利血平的致抑郁作用，而褪黑素可减弱这种作用。同时，在该模型上，急性和慢性给予松果体化合物（褪黑素、肽类）后显示出它们自身的抗抑郁活性。
