通过接种牛白血病病毒（BLV）env重组痘苗病毒增强反刍动物中BLV特异性淋巴细胞增殖反应：它们在抑制BLV复制中的作用。

Augmentation of bovine leukemia virus (BLV)-specific lymphocyte proliferation responses in ruminants by inoculation with BLV env-recombinant vaccinia virus: their role in the suppression of BLV replication.

作者信息

Ohishi K, Suzuki H, Yasutomi Y, Onuma M, Okada K, Numakunai S, Ohshima K, Ikawa Y, Sugimoto M

机构信息

Corporate Research and Development Laboratory, Tonen Corporation, Saitama, Japan.

出版信息

Microbiol Immunol. 1992;36(12):1317-23. doi: 10.1111/j.1348-0421.1992.tb02133.x.

DOI:10.1111/j.1348-0421.1992.tb02133.x

PMID:1337572

Abstract

Lymphocyte proliferation responses were investigated in sheep and cattle, in which the replication of bovine leukemia virus (BLV) had been known to be suppressed by inoculation with recombinant vaccinia virus (rVV) expressing BLV envelope glycoprotein (gp60). Enhanced lymphocyte proliferation responses were observed in animals inoculated with rVV, regardless of whether they were naive or BLV carriers. These responses were roughly inversely correlated to the growth of BLV in the peripheral blood leukocytes. In contrast, there was no apparent correlation between humoral immune response and BLV growth. Based on these results, it was suggested that rVV rendered its suppressive effect of BLV replication primarily via augmentation of cell-mediated immunity.

摘要

在绵羊和牛中研究了淋巴细胞增殖反应，已知接种表达牛白血病病毒（BLV）包膜糖蛋白（gp60）的重组痘苗病毒（rVV）可抑制BLV的复制。无论动物是未感染过BLV还是BLV携带者，接种rVV的动物均观察到淋巴细胞增殖反应增强。这些反应与外周血白细胞中BLV的生长大致呈负相关。相比之下，体液免疫反应与BLV生长之间没有明显的相关性。基于这些结果，提示rVV主要通过增强细胞介导的免疫来发挥其对BLV复制的抑制作用。