Mucsi I, Gyulai Z, Béládi I
Institute of Microbiology, Albert Szent-Györgyi University Medical School, Szeged, Hungary.
Acta Microbiol Hung. 1992;39(2):137-47.
The combined antiviral effects of some flavonoid compounds and acycloguanosine (acyclovir, Zovirax) were studied on the multiplication of herpes simplex virus types 1 and 2 in HEp-2 cells and on pseudorabies (Aujeszky) virus in chick embryo fibroblast cells by the yield reduction method. The flavonoids quercetin, quercitrin (quercetin-3-L-rhamnoside) and apigenin exhibit antiviral activity against these herpesviruses, and acyclovir is currently one of the most effective antiherpetic agents. In these studies, the simultaneous application of flavonoids with acyclovir resulted in an enhanced antiviral activity. A mathematical formula was used to interpret the drug interaction, resulting in FIC (fractional inhibitory concentration) indices. Meaning a synergic interaction, all combinations exhibited synergy, FIC values of 0.6-0.8 being commonly observed.
采用病毒产量减少法，研究了某些黄酮类化合物与阿昔洛韦（无环鸟苷，阿昔洛韦，舒维疗）联合应用对单纯疱疹病毒1型和2型在人喉表皮样癌细胞（HEp-2细胞）中增殖以及对伪狂犬病（奥耶斯基氏病）病毒在鸡胚成纤维细胞中增殖的影响。黄酮类化合物槲皮素、槲皮苷（槲皮素-3-L-鼠李糖苷）和芹菜素对这些疱疹病毒具有抗病毒活性，而阿昔洛韦是目前最有效的抗疱疹药物之一。在这些研究中，黄酮类化合物与阿昔洛韦同时应用可增强抗病毒活性。采用数学公式解释药物相互作用，得出联合抑菌浓度（FIC）指数。所有组合均表现出协同作用，即FIC值为0.6 - 0.8时通常观察到协同相互作用。
