Wleklik M, Luczak M, Panasiak W, Kobus M, Lammer-Zarawska E
Department of Virology Institute of Biostructure Medical Academy of Warsaw, Poland.
Acta Virol. 1988 Nov;32(6):522-5.
The effect of different substituents of quercetin and luteolin on the ability to inhibit the herpes simplex virus (HSV-1) replication in RK-13 cells was studied. It seems that parent compounds with free hydroxyl groups at C-5, C-7, C-3', C-4' and additionally at C-3 have the highest activity. Substitution of those groups caused decrease of or completely abolished the antiviral activity of the tested compounds.
研究了槲皮素和木犀草素不同取代基对其抑制单纯疱疹病毒1型（HSV - 1）在RK - 13细胞中复制能力的影响。似乎在C - 5、C - 7、C - 3'、C - 4'以及另外在C - 3处带有游离羟基的母体化合物具有最高活性。这些基团的取代导致测试化合物的抗病毒活性降低或完全丧失。
