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植物化合物作为牙科预防和治疗剂的来源

Vegetal Compounds as Sources of Prophylactic and Therapeutic Agents in Dentistry.

作者信息

Milutinovici Raluca-Adriana, Chioran Doina, Buzatu Roxana, Macasoi Ioana, Razvan Susan, Chioibas Raul, Corlan Ion Virgil, Tanase Alina, Horia Calniceanu, Popovici Ramona Amina, Dinu Stefania, Dehelean Cristina, Scurtu Alexandra, Pinzaru Iulia, Soica Codruta

机构信息

Departament of Orthodontics, Faculty of Dental Medicine, Victor Babeș University of Medicine and Pharmacy, 9 Revolutiei 1989 Ave., 300070 Timisoara, Romania.

Orthodontic Research Center (ORTHO-CENTER), Faculty of Dental Medicine, Victor Babes University of Medicine and Pharmacy, Revolutiei Ave. 1989 No. 9, 300041 Timisoara, Romania.

出版信息

Plants (Basel). 2021 Oct 10;10(10):2148. doi: 10.3390/plants10102148.

Abstract

Dental pathology remains a global health problem affecting both children and adults. The most important dental diseases are dental caries and periodontal pathologies. The main cause of oral health problems is overpopulation with pathogenic bacteria and for this reason, conventional therapy can often be ineffective due to bacterial resistance or may have unpleasant side effects. For that reason, studies in the field have focused on finding new therapeutic alternatives. Special attention is paid to the plant kingdom, which offers a wide range of plants and active compounds in various pathologies. This review focused on the most used plants in the dental field, especially on active phytocompounds, both in terms of chemical structure and in terms of mechanism of action. It also approached the in vitro study of active compounds and the main types of cell lines used to elucidate the effect and mechanism of action. Thus, medicinal plants and their compounds represent a promising and interesting alternative to conventional therapy.

摘要

牙科病理学仍然是一个影响儿童和成人的全球健康问题。最重要的牙科疾病是龋齿和牙周疾病。口腔健康问题的主要原因是致病细菌过多,因此,由于细菌耐药性,传统治疗往往无效,或者可能有不良副作用。因此,该领域的研究集中在寻找新的治疗方法。人们特别关注植物界,它在各种疾病中提供了广泛的植物和活性化合物。本综述聚焦于牙科领域最常用的植物,尤其是活性植物化合物,包括化学结构和作用机制方面。它还探讨了活性化合物的体外研究以及用于阐明作用效果和作用机制的主要细胞系类型。因此,药用植物及其化合物是传统治疗的一种有前景且有趣的替代方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/055e/8537575/3ef814cf0d1f/plants-10-02148-g001.jpg

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