Soodyall H, Jenkins T
Department of Human genetics, School of Pathology, South African Institute for Medical Research, Johannesburg.
Gene Geogr. 1992 Dec;6(3):127-37.
The polymorphisms of mitochondrial DNA (mtDNA) for the restriction enzymes HpaI, BamHI, HaeII, MspI, AvaII, and HincII were studied in a sample of 147 unrelated Indian individuals from South Africa, who were subdivided according to religion and language into four groups, namely, Tamil, Hindi, Gujerati and Moslem. They were found to be monomorphic with the enzymes BamHI, and HaeII, and little variation was observed with the enzymes MspI and HincII. Six individuals were found to contain the non-Caucasoid HpaI morph, HpaI-3, which is found more commonly in indigenous African populations. This suggests that some flow of maternal genes from indigenous African populations into the Indian population may have occurred. Despite these interactions, Indians in South Africa display very little mtDNA variation (F = 0.77) when compared with those living in Nepal (F = 0.35) and New Delhi (F = 0.51). When compared with other Caucasoid populations, Indians are more homogenous in their genetic structure, which may be attributable to the high level of inbreeding among them, due to strict caste endogamy and certain religious customs that are still practised by the majority of Indians today.
在来自南非的147名无亲缘关系的印度个体样本中，研究了线粒体DNA（mtDNA）对于限制性内切酶HpaI、BamHI、HaeII、MspI、AvaII和HincII的多态性。这些个体根据宗教和语言被细分为四组，即泰米尔语组、印地语组、古吉拉特语组和穆斯林组。发现它们对于BamHI和HaeII这两种酶呈单态性，并且对于MspI和HincII这两种酶观察到的变异很少。发现6名个体含有非高加索人种的HpaI形态，即HpaI - 3，这种形态在非洲本土人群中更常见。这表明可能发生了一些母系基因从非洲本土人群流入印度人群的情况。尽管存在这些相互作用，但与生活在尼泊尔（F = 0.35）和新德里（F = 0.51）的印度人相比，南非的印度人表现出的mtDNA变异非常少（F = 0.77）。与其他高加索人种群体相比，印度人的基因结构更加同质化，这可能归因于他们之间高度的近亲繁殖，这是由于严格的种姓内婚制以及当今大多数印度人仍然实行的某些宗教习俗。
