Chhabra S K, Rao A R
Cancer Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
Dev Pharmacol Ther. 1992;19(2-3):111-7. doi: 10.1159/000457472.
The present study examines the effect of butylated hydroxyanisole (BHA) exposure through mother's milk on some of the hepatic xenobiotic metabolizing enzymes in the F1 offspring. Lactating Swiss albino mice received either a 0.5 or 1% BHA diet during the lactation period. The acid-soluble sulfhydryl content and activities of glutathione S-transferase and glutathione reductase increased significantly (p < 0.01) whereas the activity of glutathione peroxidase decreased significantly (p < 0.01) in the liver of pups exposed to BHA via milk. The hepatic content of cytochrome b5 increased (p < 0.01) while that of cytochrome P-450 decreased (p < 0.01) in the pups of dams which received a 1% BHA diet during lactation.
本研究检测了通过母乳接触丁基羟基茴香醚（BHA）对F1代子代小鼠一些肝脏异生物代谢酶的影响。哺乳期的瑞士白化小鼠在哺乳期接受了含0.5%或1%BHA的饮食。通过乳汁接触BHA的幼崽肝脏中，酸溶性巯基含量以及谷胱甘肽S-转移酶和谷胱甘肽还原酶的活性显著增加（p<0.01），而谷胱甘肽过氧化物酶的活性显著降低（p<0.01）。哺乳期接受1%BHA饮食的母鼠所产幼崽肝脏中，细胞色素b5的含量增加（p<0.01），而细胞色素P-450的含量降低（p<0.01）。
