Arima K, Ando M, Ito K, Sakata T, Yamaguchi T, Araki S, Futatsuka M
First Department of Internal Medicine, Kumamoto University School of Medicine, Japan.
Arch Environ Health. 1992 Jul-Aug;47(4):274-8. doi: 10.1080/00039896.1992.9938361.
We investigated the effect of cigarette smoking on the prevalence of summer-type hypersensitivity pneumonitis (SHP) caused by Trichosporon cutaneum. In the adult family members of SHP patients, we found that 27 of 41 (65.9%) nonsmokers were SHP patients, compared with 3 of 11 (27.3%) smokers (p less than .05). Also, the prevalence of anti-T. cutaneum antibody was significantly lower in the smokers (p less than .05). A questionnaire provided to 209 SHP patients revealed that the smoking rates of male and female SHP patients were significantly lower (p less than .01) than rates in the normal Japanese population. However, no difference was found in serum anti-T. cutaneum antibody activities or the bronchoalveolar lavage lymphocyte phenotypes for smoking and nonsmoking SHP patients. It was concluded that cigarette smoking had a suppressive effect on the outbreak of SHP, but smoking caused no further suppression after the disease was established.
我们研究了吸烟对由皮状丝孢酵母引起的夏季型超敏性肺炎（SHP）患病率的影响。在SHP患者的成年家庭成员中，我们发现，41名不吸烟者中有27名（65.9%）是SHP患者，而11名吸烟者中只有3名（27.3%）是SHP患者（p小于0.05）。此外，吸烟者中抗皮状丝孢酵母抗体的患病率显著较低（p小于0.05）。对209名SHP患者进行的问卷调查显示，男性和女性SHP患者的吸烟率显著低于正常日本人群（p小于0.01）。然而，吸烟和不吸烟的SHP患者在血清抗皮状丝孢酵母抗体活性或支气管肺泡灌洗淋巴细胞表型方面没有差异。得出的结论是，吸烟对SHP的发病有抑制作用，但在疾病确立后吸烟不会导致进一步的抑制。
