Ando M, Yoshida K, Soda K, Araki S
Am Rev Respir Dis. 1986 Jul;134(1):177-9. doi: 10.1164/arrd.1986.134.1.177.
Patients with summer-type hypersensitivity pneumonitis induced by Trichosporon cutaneum were studied with respect to specific IgG, IgA, and secretory IgA (S-IgA) antibody activities to T. cutaneum in serum and bronchoalveolar lavage fluid (BALF). A strain of T. cutaneum was isolated from 1 patient's pillow. All serum samples from the family members (2 patients and 2 asymptomatic) contained IgG antibody activity to T. cutaneum, and the titers showed no difference between the patients and asymptomatic family members. On the other hand, IgA and S-IgA antibody activities in serum and BALF were markedly increased only in the patients, and the titers were well correlated with the clinical course. The BALF/serum ratio of specific antibody activity was markedly elevated in IgA and S-IgA antibody activities in striking contrast to that in IgG, suggesting an immune reaction of the respiratory tract. The bronchial challenge test with T. cutaneum antigen was positive in the patients, but not in an asymptomatic family member. These results indicate that measurement of IgA and S-IgA antibody activities in serum and BALF is useful for diagnosis and evaluation of disease activity in summer-type hypersensitivity pneumonitis.
对由皮状丝孢酵母引起的夏季型过敏性肺炎患者，研究了血清和支气管肺泡灌洗液（BALF）中针对皮状丝孢酵母的特异性IgG、IgA和分泌型IgA（S-IgA）抗体活性。从1例患者的枕头中分离出1株皮状丝孢酵母。该家庭所有成员（2例患者和2例无症状者）的血清样本均含有针对皮状丝孢酵母的IgG抗体活性，且患者与无症状家庭成员之间的滴度无差异。另一方面，仅患者血清和BALF中的IgA和S-IgA抗体活性显著升高，且滴度与临床病程密切相关。与IgG相比，IgA和S-IgA抗体活性的特异性抗体活性的BALF/血清比值显著升高，提示呼吸道存在免疫反应。皮状丝孢酵母抗原支气管激发试验在患者中呈阳性，但在无症状家庭成员中为阴性。这些结果表明，检测血清和BALF中的IgA和S-IgA抗体活性有助于夏季型过敏性肺炎的诊断和疾病活动度评估。
