人类高密度脂蛋白的免疫学研究。
Immunologic studies of human high density lipoproteins.
作者信息
DELALLA L, LEVINE L, BROWN R K
出版信息
J Exp Med. 1957 Aug 1;106(2):261-71. doi: 10.1084/jem.106.2.261.
Abstract
High density serum lipoprotein underwent serologic and physicochemical alterations on aging during storage at 0 degrees C. for 1 month, as judged by decrease of diffusion coefficient and increase of C' fixation. Ultracentrifugation, dialysis, and high concentrations of sodium chloride did not cause these changes. A protein sedimenting at density 1.24 in the ultracentrifuge reacted with antiserum to high density lipoprotein. Probably it was the protein portion of alpha lipoprotein dissociated from the lipide during ultracentrifugation. Although the antiserum to high density lipoprotein did not react with low density lipoprotein prepared from normal serum, it reacted with similarly prepared lipoproteins from the serum of a patient with biliary cirrhosis.
摘要
在0℃储存1个月期间，高密度血清脂蛋白在老化过程中发生了血清学和物理化学改变，这可通过扩散系数降低和补体（C'）结合增加来判断。超速离心、透析和高浓度氯化钠不会引起这些变化。在超速离心机中密度为1.24时沉淀的一种蛋白质与抗高密度脂蛋白抗血清发生反应。它可能是在超速离心过程中从脂质中解离出来的α脂蛋白的蛋白质部分。尽管抗高密度脂蛋白抗血清不与从正常血清制备的低密度脂蛋白发生反应，但它与从一位胆汁性肝硬化患者血清中以类似方式制备的脂蛋白发生反应。
相似文献
1
Immunologic studies of human high density lipoproteins.人类高密度脂蛋白的免疫学研究。
J Exp Med. 1957 Aug 1;106(2):261-71. doi: 10.1084/jem.106.2.261.
2
3
Plasma lipoprotein separations by zonal ultracentrifugation.通过区带超速离心法分离血浆脂蛋白
Prep Biochem. 1978;8(4):295-319. doi: 10.1080/00327487808065527.
4
Development of a lipoprotein profile using capillary electrophoresis and mass spectrometry.使用毛细管电泳和质谱法开发脂蛋白谱。
Electrophoresis. 1997 Sep;18(10):1796-806. doi: 10.1002/elps.1150181014.
5
Detection of new epitopes formed upon oxidation of low-density lipoprotein, lipoprotein (a) and very-low-density lipoprotein. Use of an antiserum against 4-hydroxynonenal-modified low-density lipoprotein.检测低密度脂蛋白、脂蛋白(a)和极低密度脂蛋白氧化后形成的新表位。使用抗4-羟基壬烯醛修饰的低密度脂蛋白抗血清。
Biochem J. 1990 Jan 15;265(2):605-8. doi: 10.1042/bj2650605.
6
Cord-blood low-density lipoprotein cholesterol: estimation versus measurement with the preparative ultracentrifuge.脐血低密度脂蛋白胆固醇：与用制备型超速离心机测量的对比评估
J Lab Clin Med. 1973 Sep;82(3):467-72.
7
[The microanalysis of serum lipoprotein lipids (author's transl)].血清脂蛋白脂质的微量分析（作者译）
J Clin Chem Clin Biochem. 1979 Oct;17(10):619-25.
8
Studies on the composition and structure of plasma lipoproteins. Distribution of lipoprotein families in major density classes of normal human plasma lipoproteins.血浆脂蛋白的组成与结构研究。正常人血浆脂蛋白主要密度类别的脂蛋白家族分布。
Biochim Biophys Acta. 1972 Apr 18;260(4):689-707.
9
Mathematical evaluation of methods for estimation of the concentration of the major lipid components of human serum lipoproteins.人血清脂蛋白主要脂质成分浓度估算方法的数学评估
J Lab Clin Med. 1976 Sep;88(3):491-505.
10
Studies on serum lipoproteins of rats developing spontaneous hyperlipidemia.对发生自发性高脂血症大鼠的血清脂蛋白的研究。
Artery. 1981;9(6):456-76.
引用本文的文献
1
HETEROGENEITY OF PLASMA HIGH DENSITY LIPOPROTEINS.血浆高密度脂蛋白的异质性
J Clin Invest. 1965 Mar;44(3):426-41. doi: 10.1172/JCI105156.
2
THE INHERITANCE OF HIGH DENSITY LIPOPROTEIN DEFICIENCY (TANGIER DISEASE).高密度脂蛋白缺乏症（丹吉尔病）的遗传
J Clin Invest. 1964 Feb;43(2):228-36. doi: 10.1172/JCI104907.
3
Triton hyperlipemia in dogs. I. In vitro effects of the detergent on serum lipoproteins and chylomcrons.犬类的 Triton 高脂血症。I. 去污剂对血清脂蛋白和乳糜微粒的体外作用。
J Exp Med. 1961 Apr 1;113(4):735-57. doi: 10.1084/jem.113.4.735.
4
Studies on the antigenicity of beta- and alpha-lipoproteins of human serum.人血清β脂蛋白和α脂蛋白抗原性的研究。
J Exp Med. 1958 Aug 1;108(2):185-96. doi: 10.1084/jem.108.2.185.
5
A lipoprotein characterizing obstructive jaundice. II. Isolation and partial characterization of the protein moieties of low density lipoproteins.一种表征梗阻性黄疸的脂蛋白。II. 低密度脂蛋白蛋白质部分的分离及部分特性分析
J Clin Invest. 1970 Dec;49(12):2396-407. doi: 10.1172/JCI106459.
6
A lipoprotein characterizing obstructive jaundice: isolation and analysis.一种表征梗阻性黄疸的脂蛋白：分离与分析。
Trans Am Clin Climatol Assoc. 1970;81:98-106.
7
A lipoprotein characterizing obstructive jaundice. I. Method for quantitative separation and identification of lipoproteins in jaundiced subjects.一种表征梗阻性黄疸的脂蛋白。I. 黄疸患者脂蛋白的定量分离与鉴定方法。
J Clin Invest. 1969 Jul;48(7):1211-23. doi: 10.1172/JCI106085.
8
[The subdivisibility of human lipoproteins of low density with regard to their Lp(a)-property with ion-exchange-column chromatography].[关于低密度人类脂蛋白的Lp(a)特性通过离子交换柱色谱法的可细分性]
Blut. 1968 Dec;18(3):160-71. doi: 10.1007/BF01632424.
9
[Advances in the analysis of plasma lipoproteins. A new possibility for differential diagnosis of icterus].[血浆脂蛋白分析的进展。黄疸鉴别诊断的新可能性]
Klin Wochenschr. 1970 Jan 1;48(1):1-4. doi: 10.1007/BF01486121.
10
Plasma lipoproteins in liver disease. I. Immunologically distinct low-density lipoproteins in patients with biliary obstruction.肝脏疾病中的血浆脂蛋白。I. 胆道梗阻患者中免疫特性不同的低密度脂蛋白。
J Clin Invest. 1967 Nov;46(11):1855-66. doi: 10.1172/JCI105676.
本文引用的文献
1
THE ACTIVATING EFFECT OF MAGNESIUM AND OTHER CATIONS ON THE HEMOLYTIC FUNCTION OF COMPLEMENT.镁及其他阳离子对补体溶血功能的激活作用。
J Exp Med. 1946 Nov 30;84(6):535-48. doi: 10.1084/jem.84.6.535.
2
A QUANTITATIVE THEORY OF THE PRECIPITIN REACTION : III. THE REACTION BETWEEN CRYSTALLINE EGG ALBUMIN AND ITS HOMOLOGOUS ANTIBODY.定量沉淀反应理论：III. 晶体卵清蛋白与其同源抗体的反应。
J Exp Med. 1935 Oct 31;62(5):697-720. doi: 10.1084/jem.62.5.697.
3
A simplified method for the estimation of total cholesterol in serum and demonstration of its specificity.一种估算血清总胆固醇的简化方法及其特异性验证。
J Biol Chem. 1952 Mar;195(1):357-66.
4
5
Diagnostic complement fixation. I. A method.诊断性补体结合试验。I. 一种方法。
Am J Syph Gonorrhea Vener Dis. 1952 Mar;36(2):140-53.
6
Serum lipoproteins; chemical and enzymatic studies.血清脂蛋白；化学与酶学研究
Clin Chem. 1955 Apr;1(2):83-92.
7
Immunochemical heterogeneity of human plasma lipoproteins.人血浆脂蛋白的免疫化学异质性
Nature. 1957 Jan 26;179(4552):203-4. doi: 10.1038/179203a0.
8
Immunochemical studies on human plasma lipoproteins.人类血浆脂蛋白的免疫化学研究。
J Exp Med. 1957 Jan 1;105(1):49-67. doi: 10.1084/jem.105.1.49.
9
N-terminal residues of serum lipoproteins.
Biochim Biophys Acta. 1956 Jun;20(3):557-8. doi: 10.1016/0006-3002(56)90354-7.
10
Zotero 插件