Wade W G, Addy M
Department of Periodontology, University of Wales College of Medicine, Cardiff, UK.
J Periodontol. 1992 Apr;63(4):280-2. doi: 10.1902/jop.1992.63.4.280.
The antibacterial activity of 4 triclosan-containing toothpastes was compared to a conventional fluoride dentifrice and triclosan and sodium lauryl sulphate (SLS), both singly and in combination. A panel of 17 bacteria was tested by an agar dilution method. At concentrations typical of those found in toothpastes, triclosan and SLS displayed approximately equal antibacterial activity. A paste containing triclosan and zinc citrate appeared more active than the other triclosan pastes which, in general, showed marginal superiority over the conventional paste. SLS, although included in dentifrice formulations for its detergent properties, may significantly contribute to the antibacterial profile of a product. The need for appropriate controls when evaluating experimental toothpastes is emphasized.
将4种含三氯生的牙膏的抗菌活性与一种传统含氟牙膏以及三氯生和月桂醇硫酸酯钠（SLS）进行了比较，三氯生和SLS分别使用以及联合使用。通过琼脂稀释法对一组17种细菌进行了测试。在牙膏中常见的浓度下，三氯生和SLS表现出大致相同的抗菌活性。一种含有三氯生和柠檬酸锌的牙膏似乎比其他含三氯生的牙膏活性更高，而其他含三氯生的牙膏总体上比传统牙膏略具优势。SLS虽然因其清洁性能而被纳入牙膏配方中，但可能对产品的抗菌特性有显著贡献。强调了在评估实验性牙膏时进行适当对照的必要性。
