通过对微小突触电流的分析揭示突触后对长时程增强的作用。
Postsynaptic contribution to long-term potentiation revealed by the analysis of miniature synaptic currents.
作者信息
Manabe T, Renner P, Nicoll R A
机构信息
Department of Pharmacology, University of California, San Francisco 94143-0450.
出版信息
Nature. 1992 Jan 2;355(6355):50-5. doi: 10.1038/355050a0.
DOI:10.1038/355050a0
PMID:1346229
Abstract
Miniature excitatory synaptic currents were recorded from CA1 pyramidal cells in hippocampal slices to study the site of the persistent change in synaptic efficacy during long-term potentiation. Induction of long-term potentiation produced a large increase in the amplitude of these currents. Such a change in amplitude suggests an increase in postsynaptic transmitter sensitivity.
摘要
从海马切片中的CA1锥体神经元记录微小兴奋性突触电流，以研究长时程增强过程中突触效能持续变化的位点。长时程增强的诱导使这些电流的幅度大幅增加。这种幅度变化表明突触后递质敏感性增加。
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