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人类10号染色体微卫星多态性的连锁图谱

Linkage mapping of human chromosome 10 microsatellite polymorphisms.

作者信息

Decker R A, Moore J, Ponder B, Weber J L

机构信息

Marshfield Medical Research Foundation, Wisconsin 54449.

出版信息

Genomics. 1992 Mar;12(3):604-6. doi: 10.1016/0888-7543(92)90455-2.

DOI:10.1016/0888-7543(92)90455-2
PMID:1348490
Abstract

Ten microsatellite DNA polymorphisms located on human chromosome 10 were regionally mapped using subchromosomal somatic cell hybrids and linkage analysis. The resulting order of the markers from pter-qter was [D10S89, D10S111], D10S107, D10S109, [D10S91, D10S110, D10S108, D10S88, D10S168], and D10S169. Order of the markers within brackets was uncertain, although the order given was most likely. The microsatellites were distributed along the chromosome from the proximal p arm to near qter, with an unlinked gap between D10S168 and D10S169.

摘要

利用亚染色体体细胞杂种和连锁分析,对位于人类10号染色体上的10个微卫星DNA多态性进行了区域定位。从染色体短臂末端(pter)到长臂末端(qter),标记的最终顺序为[D10S89, D10S111]、D10S107、D10S109、[D10S91, D10S110, D10S108, D10S88, D10S168]和D10S169。括号内标记的顺序不确定,尽管给出的顺序最有可能。微卫星沿着染色体从近端的短臂(p臂)分布到接近长臂末端(qter),在D10S168和D10S169之间存在一个不连锁的间隙。

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