Miller J R, Thomsen P D, Dixon S C, Tucker E M, Konfortov B A, Harbitz I
Department of Molecular Physiology, Cambridge Research Station, Babraham, UK.
Anim Genet. 1992;23(1):51-8.
A panel of bovine-murine hybrid cell lines was analysed for 10 loci, including three (IGF1, IGHG2 and the calcium release channel gene [CRC]) that have previously been mapped in man, but not in cattle. The IGF and CRC genes were indirectly mapped to chromosomes 5 and 18 respectively and the syntenies of the HOX2 and GH genes and of the NP and FOS genes were confirmed. The results also show that the IGHG2 locus, which is linked to NP and FOS on human chromosome 14, is separated from these genes in cattle. By showing synteny of the IGHG2 and MPI loci, the IGHG2 locus has been indirectly mapped to chromosome 21.
对一组牛 - 鼠杂交细胞系进行了10个基因座的分析，其中包括三个基因座（胰岛素样生长因子1基因[IGF1]、免疫球蛋白重链γ2基因[IGHG2]和钙释放通道基因[CRC]），这些基因座先前已在人类中定位，但尚未在牛中定位。IGF基因和CRC基因分别被间接定位到5号和18号染色体上，并且证实了HOX2和GH基因以及NP和FOS基因的同线性。结果还表明，在人类14号染色体上与NP和FOS基因连锁的IGHG2基因座在牛中与这些基因分离。通过显示IGHG2基因座和磷酸甘露糖异构酶基因[MPI]的同线性，IGHG2基因座已被间接定位到21号染色体上。
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