隐睾的治疗：促黄体生成激素释放激素（LHRH）的可疑价值。一项双盲、安慰剂对照的多中心研究。

Management of the non-descended testis: doubtful value of luteinizing-hormone-releasing-hormone (LHRH). A double-blind, placebo-controlled multicentre study.

作者信息

Olsen L H, Genster H G, Mosegaard A, Jørgensen F S, Hofman N, Jensen V B, Lassen L B, Rassmussen M, Vinzents L, Dammegaard L

机构信息

Department of Paediatrics, Silkeborg Hospital, Esbjerg Hospital, Denmark.

出版信息

Int J Androl. 1992 Apr;15(2):135-43. doi: 10.1111/j.1365-2605.1992.tb01122.x.

DOI:10.1111/j.1365-2605.1992.tb01122.x

PMID:1349301

Abstract

In a double-blind, placebo-controlled multicentre study, the effect of luteinizing-hormone-releasing-hormone (LHRH) in 141 boys was analysed after 4-week treatment period with 0.4 mg LHRH nasal spray or placebo nasal spray three times daily. Data from 123 boys was analysed, with 62 boys in the treatment group and 61 in the placebo group. Full response i.e. the testis at the bottom of the scrotum on both sides in boys with bilaterally undescended testes, was found in six patients, one of them in the placebo group [Therapeutic gain of LHRH with 95% CI: 8.1% (0.1-16.6%, P = 0.12)]. Only in these boys could surgery be avoided. Considering the number of testes (and not the number of boys) a significant effect was found on at least one testis in 25% of boys with bilaterally undescended testes [Therapeutic gain with 95% CI: 24.0% (13.2-34.8%, P = 0.001)]. In unilateral undescended testes, the LHRH treatment showed no effect (P = 1.00). The inclusion of retractile testes did not affect our results. In our opinion LHRH has a limited place in treatment of the non-descended testis.

摘要

在一项双盲、安慰剂对照的多中心研究中，对141名男孩使用0.4毫克促黄体生成激素释放激素（LHRH）鼻喷雾剂或安慰剂鼻喷雾剂，每日三次，治疗4周后分析LHRH的效果。分析了123名男孩的数据，治疗组62名男孩，安慰剂组61名男孩。完全反应即双侧隐睾男孩双侧睾丸降至阴囊底部，在6名患者中发现，其中1名在安慰剂组[LHRH的治疗获益及95%置信区间：8.1%（0.1 - 16.6%，P = 0.12）]。只有在这些男孩中可以避免手术。考虑到睾丸的数量（而非男孩的数量），在25%的双侧隐睾男孩中，至少有一个睾丸有显著效果[治疗获益及95%置信区间：24.0%（13.2 - 34.8%，P = 0.001）]。在单侧隐睾中，LHRH治疗无效果（P = 1.00）。纳入回缩性睾丸不影响我们的结果。我们认为LHRH在隐睾治疗中的作用有限。