Chauhan A, Dilawari J B, Jameel S, Kaur U, Chawla Y K, Sharma M L, Ganguly N K
Department of Hepatology, Post-Graduate Institute of Medical Education and Research, Chandigarh, India.
Lancet. 1992 Jun 20;339(8808):1509-10. doi: 10.1016/0140-6736(92)91267-c.
Enterovirus-like particles have been reported in the acute phase of both epidemic and sporadic non-A, non-B (NANB) hepatitis. To examine whether these particles were the causative agent in the two types of disease, 29 patients with acute viral hepatitis in a north Indian epidemic outbreak and 9 with sporadic acute disease were investigated. 25 (86%) of 29 patients with epidemic hepatitis and 5 (56%) of 9 with sporadic disease were diagnosed as having enterically-transmitted-NANB hepatitis by exclusion. Virus-like particles (VLP) of 30-34 nm were detected in stool of 1 patient with epidemic and 1 with sporadic hepatitis. The VLPs crossreacted serologically and a specific IgM response was seen in acute epidemic and sporadic serum samples. After inoculation with infected stool rhesus monkeys had a mild rise in liver enzymes, and bile samples contained VLPs. These results suggest that the aetiological agent in epidemic and sporadic disease is the same.
在流行性和散发性非甲非乙型（NANB）肝炎的急性期均有肠道病毒样颗粒的报道。为了检验这些颗粒是否为这两种疾病的病原体，对印度北部一次流行性肝炎暴发中的29例急性病毒性肝炎患者以及9例散发性急性肝炎患者进行了调查。通过排除法，29例流行性肝炎患者中有25例（86%）以及9例散发性肝炎患者中有5例（56%）被诊断为经肠道传播的NANB肝炎。在1例流行性肝炎患者和1例散发性肝炎患者的粪便中检测到了30 - 34纳米的病毒样颗粒（VLP）。这些VLP在血清学上发生交叉反应，并且在急性流行性和散发性血清样本中均出现了特异性IgM反应。用感染的粪便接种恒河猴后，其肝酶有轻度升高，胆汁样本中含有VLP。这些结果表明，流行性和散发性疾病的病原体是相同的。
