Brooks C D, Nelson A L, Metzler C
J Allergy Clin Immunol. 1984 May;73(5 Pt 1):584-9. doi: 10.1016/0091-6749(84)90515-3.
To test whether prostaglandins contribute to the nasal allergic reaction, we subjected allergic rhinitis patients to nasal allergen challenge after treatment with flurbiprofen, a cyclooxygenase inhibitor. We challenged 18 patients after two pretreatment doses of flurbiprofen, 75 mg, chlorpheniramine, 6 mg, both drugs combined, and placebo. All patients received all treatments. None of the treatments affected measured nasal airway resistance. Nasal secretion weight, number of sneezes, and overall subjective severity scores for all active treatments differed significantly from placebo treatment. Flurbiprofen proved nearly as effective as chlorpheniramine in reducing severity of induced rhinitis. Some mechanism that can be influenced by flurbiprofen (possibly prostaglandin synthesis) contributes to the acute, induced allergic reaction.
为了测试前列腺素是否会导致鼻部过敏反应，我们在用环氧化酶抑制剂氟比洛芬治疗后，对过敏性鼻炎患者进行了鼻内过敏原激发试验。我们对18名患者进行了试验，分别给予他们两剂预处理药物，75毫克氟比洛芬、6毫克氯苯那敏、两种药物联用，以及安慰剂。所有患者都接受了所有治疗。没有一种治疗方法影响所测的鼻气道阻力。所有有效治疗组的鼻分泌物重量、打喷嚏次数和总体主观严重程度评分与安慰剂治疗组相比均有显著差异。在减轻诱发鼻炎的严重程度方面，氟比洛芬被证明几乎与氯苯那敏一样有效。氟比洛芬能够影响的某种机制（可能是前列腺素合成）导致了急性诱发过敏反应。
