McLean J A, Bacon J R, Mathews K P, Banas J, Capati D, Bayne N K
J Allergy Clin Immunol. 1983 Aug;72(2):187-92. doi: 10.1016/0091-6749(83)90528-6.
Preliminary experiments indicated that solutions of aspirin (ASA) in buffered saline, pH 7.35, did not significantly change nasal airways resistance (NAR) when 0.1 ml of solution containing 22.5 mg (or less) per deciliter was sprayed into each nostril. Subsequently it was shown that this quantity of ASA administered intranasally did not significantly change NAR responses 15 min later to intranasal administration of increasing concentrations of histamine, methacholine, or an irritant (NH3 gas). However, the same atopic subjects demonstrated significantly decreased responses to intranasal challenge with short ragweed extract (SRW) after intranasal ASA. In addition, prior oral administration of ASA, Na salicylate, and indomethacin significantly inhibited nasal challenge responses to SRW in sensitive subjects under controlled conditions.
初步实验表明，当将每分升含22.5毫克（或更少）的0.1毫升溶液喷入每个鼻孔时，阿司匹林（ASA）在pH 7.35的缓冲盐水中的溶液不会显著改变鼻气道阻力（NAR）。随后发现，鼻内给予该剂量的ASA在15分钟后不会显著改变鼻内给予递增浓度组胺、乙酰甲胆碱或刺激物（NH3气体）时的NAR反应。然而，相同的特应性受试者在鼻内给予ASA后，对短豚草提取物（SRW）鼻内激发的反应显著降低。此外，在对照条件下，预先口服ASA、水杨酸钠和吲哚美辛可显著抑制敏感受试者对SRW的鼻激发反应。
