Jaehne J, Urmacher C, Thaler H T, Friedlander-Klar H, Cordon-Cardo C, Meyer H J
Clinic for Abdominal and Transplantation Surgery, Medical School Hannover, Federal Republic of Germany.
J Cancer Res Clin Oncol. 1992;118(6):474-9. doi: 10.1007/BF01629433.
The expression of the Her2/neu gene product p185 was retrospectively analyzed in 58 patients with gastric carcinoma. The results were correlated to various clinicopathological and prognostic factors. Positive membrane staining for p185 could be detected in 38% of the patients (22/58). Membrane staining was significantly greater in well and moderately differentiated tumors of the intestinal type when compared with poorly differentiated lesions and carcinomas of the diffuse type (P less than 0.01). Positive membrane staining did not correlate with site and tumor stage, but T1 lesions had less membrane staining than more advanced primary tumors. Overall survival showed no difference between p185-positive and negative cases. Multivariate analysis defined a subgroup of curatively resected patients with stage III and IV disease that had a statistically significant poorer survival when p185 was overexpressed (P = 0.005). Overexpression of the Her2/neu product p185 appears to be associated with intestinal-type gastric carcinoma and may help in identifying a subset of patients at increased risk for shorter survival.
对58例胃癌患者的Her2/neu基因产物p185的表达进行了回顾性分析。结果与各种临床病理和预后因素相关。38%的患者（22/58）可检测到p185膜染色阳性。与低分化病变和弥漫型癌相比，肠型高分化和中分化肿瘤的膜染色明显更强（P<0.01）。膜染色阳性与肿瘤部位和分期无关，但T1期病变的膜染色比更晚期的原发性肿瘤少。p185阳性和阴性病例的总生存率无差异。多变量分析确定了一组III期和IV期疾病的根治性切除患者亚组，当p185过度表达时，其生存率在统计学上显著较差（P = 0.005）。Her2/neu产物p185的过度表达似乎与肠型胃癌有关，可能有助于识别生存期缩短风险增加的患者亚组。
